Bad Heparin

Andrew Zajac's picture
Submitted by Andrew Zajac on Thu, 04/10/2008 - 12:48.

We have run into some bad heparin.   We collected data and I will post it here.  We stopped collecting data when the results started to get better.  We figured that someone may have left a box of heparin laying in the sun too long, because we had heparin from the same lot number that would sometimes work fine, and somtimes not.

 

The Heparin we use is Hepalean  by Organon.  We use 10ml and 30ml vials of 1000 units per cc.

 

 Case number  Initial Dose (units/Kg) Initial ACT (seconds)  Total heparin Given  Lot Numbers 
 1  285  482  65K  7H01 and 7E03
 2  314  348  70K  same
 3  322  422  100K  same
 4  402  585  55K  same
 5  309  561  60K  same
 6  303  543  50K  same
 7  352  969  40K  same
 8  297  508  55K  same
 9  447  1000  40K  same
 10  298  491  32K  same
 11  320   403   55K   same
 12   344  386   70K   same
 13   379   585   60K   same
 14   307   463   70K   same
 15   625   999   40K   same
 16   288   427   45K   same
 17   425   510   75K   same
 18  275  502  60K  same
 19   300   537   40K  same
 20   297   443   60K   same
 21   373   455   55K   same
 22   341   999   40K   same

 

peter allen's picture
Submitted by peter allen (not verified) on Thu, 05/15/2008 - 09:33.

Andrew besides needing more heparin were there any othe adverse events noted postoperatively ie bleeding?

Peter

Andrew Zajac's picture
Submitted by Andrew Zajac on Fri, 05/16/2008 - 11:42.

No, there was not.